Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/adodb/adodb.inc.php on line 893

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/adodb/adodb.inc.php on line 1918

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/adodb/adodb.inc.php on line 1990

Deprecated: mysql_connect(): The mysql extension is deprecated and will be removed in the future: use mysqli or PDO instead in /www/htdocs/w00a10d9/html/includes/classes/adodb/drivers/adodb-mysql.inc.php on line 360

Deprecated: Function split() is deprecated in /www/htdocs/w00a10d9/html/includes/pnLang.php on line 62

Strict Standards: Declaration of pnRender::clear_cache() should be compatible with Smarty::clear_cache($tpl_file = NULL, $cache_id = NULL, $compile_id = NULL, $exp_time = NULL) in /www/htdocs/w00a10d9/html/includes/pnRender.class.php on line 45

Strict Standards: Declaration of pnRender::is_cached() should be compatible with Smarty::is_cached($tpl_file, $cache_id = NULL, $compile_id = NULL) in /www/htdocs/w00a10d9/html/includes/pnRender.class.php on line 45

Strict Standards: Declaration of pnRender::fetch() should be compatible with Smarty::fetch($resource_name, $cache_id = NULL, $compile_id = NULL, $display = false) in /www/htdocs/w00a10d9/html/includes/pnRender.class.php on line 45

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 41

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 42

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 43

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 44

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 45

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 46

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 47

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 48

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 49

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 50

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 51

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 52

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 53

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 54

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 41

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 42

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 43

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 44

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 45

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 46

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 47

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 48

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 49

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 50

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 51

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 52

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 53

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 54

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 41

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 42

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 43

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 44

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 45

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 46

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 47

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 48

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 49

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 50

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 51

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 52

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 53

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 54

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 41

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 42

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 43

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 44

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 45

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 46

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 47

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 48

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 49

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 50

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 51

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 52

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 53

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 54

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 41

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 42

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 43

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 44

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 45

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 46

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 47

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 48

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 49

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 50

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 51

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 52

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 53

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/pnAntiCracker.php on line 54

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/safehtml.php on line 607

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 161

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 163

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 164

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 165

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 167

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 168

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 169

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 244

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 251

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 260

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 267

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 274

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 281

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 289

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 486

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 488

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/includes/classes/safehtml/HTMLSax3.php on line 490

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 51

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 51

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 51

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 51

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 51

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 53

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 54

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 55

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 56

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 57

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 58

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 63

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 64

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 64

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 65

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 66

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 67

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 68

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 69

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 70

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/includes/legacy/counter.php on line 71

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/modules/Xanthia/pnuserapi.php on line 70

Deprecated: Assigning the return value of new by reference is deprecated in /www/htdocs/w00a10d9/html/modules/Xanthia/pnuserapi.php on line 119

Strict Standards: Declaration of pnCEHTML::URL() should be compatible with pnHTML::URL($url = '', $text = '') in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 238

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 16

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 18

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 20

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 22

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 45

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 47

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 48

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 50

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 52

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 54

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 56

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 58

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 60

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 62

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 16

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 18

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 20

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 22

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 45

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 47

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 48

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 50

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 52

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 54

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 56

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 58

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 60

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 62

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/header.php on line 30
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Strict Standards: Non-static method ADOConnection::UnixTimeStamp() should not be called statically, assuming $this from incompatible context in /www/htdocs/w00a10d9/html/includes/classes/adodb/adodb.inc.php on line 3007

Strict Standards: Non-static method ADOConnection::UnixTimeStamp() should not be called statically, assuming $this from incompatible context in /www/htdocs/w00a10d9/html/includes/classes/adodb/adodb.inc.php on line 3007

Strict Standards: Non-static method ADOConnection::UnixTimeStamp() should not be called statically, assuming $this from incompatible context in /www/htdocs/w00a10d9/html/includes/classes/adodb/adodb.inc.php on line 3007

Strict Standards: Non-static method ADOConnection::UnixTimeStamp() should not be called statically, assuming $this from incompatible context in /www/htdocs/w00a10d9/html/includes/classes/adodb/adodb.inc.php on line 3007

Strict Standards: Non-static method ADOConnection::UnixTimeStamp() should not be called statically, assuming $this from incompatible context in /www/htdocs/w00a10d9/html/includes/classes/adodb/adodb.inc.php on line 3007

Strict Standards: Non-static method ADOConnection::UnixTimeStamp() should not be called statically, assuming $this from incompatible context in /www/htdocs/w00a10d9/html/includes/classes/adodb/adodb.inc.php on line 3007

Strict Standards: Non-static method ADOConnection::UnixTimeStamp() should not be called statically, assuming $this from incompatible context in /www/htdocs/w00a10d9/html/includes/classes/adodb/adodb.inc.php on line 3007

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 16

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 18

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 20

Deprecated: Function eregi() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 22

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 45

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 47

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 48

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 50

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 52

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 54

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 56

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 58

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 60

Deprecated: Function ereg() is deprecated in /www/htdocs/w00a10d9/html/modules/ContentExpress/pneditor/pnCEHTML.php on line 62

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /www/htdocs/w00a10d9/html/includes/pnAPI.php on line 589

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Karl Landsteiner

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Landsteiner, Karl, * 14. 6. 1868 Wien, † 26. 6. 1943 New York (USA), Arzt, bedeutender Serologe, Nobelpreisträger. 1896 Assistent am Hygienischen und 1898 am Pathologisch-anatomischen Institut in Wien. Beschäftigte sich besonders mit der Untersuchung des menschlichen Bluts und entdeckte 1900 dessen Agglutination (Zusammenballung) bei Berührung mit dem Blut bestimmter Menschen. 1901 stellte er die Verschiedenheit des Bluts bei verschiedenen Menschen fest und wählte die Bezeichnungen 'Gruppe A', 'Gruppe B' und 'Gruppe C'. 1908-19 Vorstand der Prosektur am Wiener Wilhelminenspital und Universitäts-dozent für Pathologische Anatomie. Nach Ende des 1. Weltkriegs folgte Landsteiner einer Berufung nach Den Haag und 1922 an das Rockefeller-Institut in New York, an dem er bis 1939 wirkte. 1927 entdeckte er mit P. Levine die Blutfaktoren M, N und P und konnte bald darauf bereits 36 Typen des menschlichen Bluts nachweisen. 1930 erhielt er den Nobelpreis für Medizin. 1940 entdeckte er (mit A. S. Wiener) den Rhesusfaktor.

Karl Landsteiner wurde am 14. Juni 1868 als einziges Kind des bekannten Journalisten Dr. Leopold Landsteiner und seiner Frau Fanny Hess Landsteiner in Wien geboren. Sein Vater war Pariskorrespondent für mehrere deutsche Zeitungen und Gründer der Tageszeitung PRESSE. Karl war erst sechs Jahre alt, als sein Vater an einem Herzinfarkt verstarb, ein Schicksalsschlag, von dem er sich nur schwer erholte. Karl kam nun unter die Obhut eines Freundes der Familie, konnte aber einen engen Kontakt zu seiner Mutter aufrechterhalten. Er besuchte das Staatsgymnasium im 9. Wiener Gemeindebezirk und legte im Jahre 1885 die Reifeprüfung mit genügendem Erfolg ab. Zum Arzt berufen, promovierte er 1891 zum Doktor der gesamten Heilkunde an der Wiener Medizinischen Fakultät. Bereits als Student beteiligte er sich an wissenschaftlichen Studien im speziellen über die Auswirkungen von Diäten auf die Zusammensetzung der Blutasche, welche 1891 veröffentlicht wurden. Danach arbeitete er als Hospitant an der Klinik für interne Medizin und beschäftigte sich in weiterer Folge mit chemischen Untersuchungen am Polytechnikum in Zürich und an den Universitäten von Würzburg und München. In den Jahren 1894 und 1895 war er Operationszögling bei Theodor Billroth an der chirurgischen Klinik in Wien. 1896 wurde er Assistent von Max Gruber am Hygiene Institut in Wien.

Von 1898 bis 1908 hatte er eine Assistentenstelle am pathologisch-anatomischen Institut inne (Vorstand A. Weichselbaum). In jener Zeit beschäftigte sich Landsteiner mit der Frage, warum man Blut nicht immer gefahrlos übertragen konnte. Er führte dabei Versuche von verblüffender Einfachheit durch. Er sammelte Blutproben seiner Mitarbeiter, den Doktoren Erdheim, Pletschnig, Störk und Sturli. Zusätzlich entnahm er sich selbst Blut und trennte die Stichproben in zellfreie Plasmaflüssigkeit und in rote Blutkörperchen. Anschließend vermischte er alle Plasmaproben mit den jeweils fremden roten Blutkörperchen. Dabei stellte sich heraus, dass das Plasma in manchen Fällen mit den roten Blutkörperchen gut sichtbare Klumpen bildete. Die heftigen Verklumpungen traten mit einer auffallenden Regelmäßigkeit auf, aber die roten Blutkörperchen von Landsteiner und Störk verklumpten gar nicht. Landsteiner zog daraus den Schluss, dass es verschiedene Blutgruppen geben müsse, er nannte sie A, B und AB. Der nicht klumpenden Sorte gab er die Bezeichnung Null. Die von Landsteiner entdeckten Blutgruppen nennt man heute das AB0-System. Erst diese Entdeckung machte gefahrlose Bluttransfusionen und schwierige chirurgische Eingriffe, für die man Blutkonserven benötigte, überhaupt erst möglich. Aufbauend auf Landsteiner´s Arbeiten wurde im Jahr 1907 die erste erfolgreiche Transfusion durch Dr. Reuben Ottenberg im Mt. Sinai Hospital, New York durchgeführt. Landsteiner´s Errungenschaften retteten vielen Soldaten das Leben auf den Schlachtfeldern des ersten Weltkrieges, wo zum ersten Mal kompatible Bluttransfusionen in großem Stile vorgenommen wurden.

Im Jahr 1902 wurde Landsteiner Vollmitglied der Gesellschaft der Ärzte in Wien.

Von 1908 bis 1919 war Landsteiner Vorstand der Prosektur am Wiener Wilhelminenspital. Er verfeinerte die Wassermann-Methode bei der Syphilis-Diagnose und beschrieb erstmalig Haptene als immunologische Besonderheit. Er forschte über die Ursache der Poliomyelitis und fand den Weg zur Herstellung des Serums, das Jahrzehnte später dem amerikanischen Forscher Jonas Salk die Herstellung des Impfstoffs gegen Kinderlähmung ermöglichte. Da er nach dem ersten Weltkrieg in Wien keine Zukunft für seine wissenschaftlichen Arbeiten sah, übernahm er 1919 die Prosektur eines kleinen Krankenhauses in Den Haag, 1922 wurde er nach Amerika an das Rockefeller Institute for Medical Research in New York berufen.

1940 gelang Landsteiner und seinem Team eine weitere bahnbrechende Entdeckung auf dem Gebiet der Blutgruppenantigene. Landsteiner entdeckte, dass sich die aus Kaninchen gewonnenen Antikörper, die sich gegen rote Blutkörperchen der Affenart 'Macaca rhesus' richten, auch gegen menschliche Blutkörperchen Reaktionen zeigen. Es stellte sich heraus, dass nur bei einem Teil der Menschen diese Reaktion stattfindet. Diesen Reaktionstypus nannte man aufgrund der Versuchsreihe mit den Rhesus-Affen 'Rhesus positiv', kurz Rh+. Die Blutgruppe, deren Blutkörperchen nicht reagierten, nannte man 'Rhesus negativ'. 85 % der Menschen sind Rhesus-positiv. Bei 15% der Menschen fehlt dieses Merkmal, sie sind daher Rhesus-negativ. Injiziertes Rh-positives Blut erzeugt im Körper eines Rh-negativen Menschen so genannte Agglutinine und Hämolysine (Antikörper), die bei einer späteren zweiten Blutübertragung zu schweren Zwischenfällen führen. Rh-positive Kinder einer Rh-negativen Mutter können ebenfalls das Auftreten solcher Antikörper im mütterlichen Blut auslösen. Treten diese während der Schwangerschaft ins Kindliche Blut über, kann es zu einer schweren Schädigung des Kindes kommen. Dies ist die häufigste Ursache der schweren Neugeborenen-Gelbsucht. Heutzutage wird diese Krankheit jedoch relativ einfach durch die Rhesusprophylaxe verhindert; man impft der Mutter Antikörper gegen das Rhesus-Antigen und unterbindet damit die mütterliche Immunantwort.

In seinen letzten Lebensjahren studierte er Onkologie, um seiner an einem bösartigen Schilddrüsengeschwür erkrankten Gattin Helene helfen zu können. Erschöpft und verzweifelt erlitt er am 26. Juni 1943, kurz nach seinem 75. Geburtstag, in seinem Laboratorium einen Schlaganfall und starb zwei Tage darauf. Seine Frau überlebte ihn um ein halbes Jahr.

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